Publications
- 10 May 2016The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the RatReference: Milani D, Knuckey NW, Cross JL, Anderton RS, Meloni BP (2016). The R18 poly-arginine peptide is more effective than the TAT-NR2B9c (NA-1) peptide when administered 60 minutes after permanent middle cerebral artery occlusion in the rat. Stroke Research and Treatment, 2016:2372710. DOI: 10.1155/2016/2372710..
- 03 May 2016Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke modelReference: Milani D, Clark VW, Cross JL, Anderton RS, Knuckey NW, Meloni BP (2016). Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model. BMC Neuroscience, 17:19. DOI: 10.1186/s12868-016-0253-z.
- 20 Nov 2016The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic MechanismsReference: MacDougall G, Anderton RS, AB, Knuckey NW, Meloni BP (2017). The neuroprotective peptide poly-arginine-12 (R12) reduces cell surface levels of NMDA NR2B receptor subunit in cortical neurons; investigation into the involvement of endocytic mechanisms. Journal of Molecular Neuroscience, 61:235-246. DOI: 10.1007/s12031-016-0861-1.
- 11 Jan 2017Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the ratReference: Milani D, Cross JL, Anderton RS, Blacker DJ, Knuckey NW, Meloni BP (2017). Neuroprotective efficacy of R18 poly-arginine and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat. Neuroscience Research, 114:9-15. doi:10.1016/j.neures.2016.09.002
- 18 May 2017Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine–Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in RatsReference: Meloni BP, Milani, D, Cross, JL, Clark VW, Edwards AB, Anderton, RS, Blacker, DJ, Knuckey, NW (2017). Assessment of the neuroprotective effects of arginine-rich protamine peptides, poly-arginine peptides (R12-cylic, R22) and arginine-tryptophan containing peptides following in vitro excitotoxicity and/or permanent middle cerebral artery occlusion in rats. Neuromolecular Medicine, 19:271-285. DOI: 10.1007/s12017-017-8441-2.
- 01 Oct 2017Delayed 2-h post-stroke administration of R18 and NA-1 (TAT-NR2B9c) peptides after permanent and/or transient middle cerebral artery occlusion in the ratReference: Milani D, Cross JL, Anderton RS, Blacker DJ, Knuckey NW, Meloni BP (2017). Delayed 2-hour post-stroke administration of R18 and NA-1 (TAT-NR2B9c) peptides after permanent and/or transient middle cerebral artery occlusion in the rat. Brain Research Bulletin,135:62-68. DOI: 10.1016/j.brainresbull.2017.09.012.
- 15 Nov 2017Assessment of R18, COG1410, and APP96-110 in excitotoxicity and traumatic brain injuryReference: Chiu LS, Anderton RS, Cross, JL, Clark VW, Edwards AB, Knuckey NW, Meloni BP. (2017). Assessment of neuroprotective peptides poly-arginine R18, COG1410, and APP96-110 experimental traumatic brain injury and in vitro neuronal excitotoxicity. Translational Neuroscience, 8:147-157. DOI: 10.1515/tnsci-2017-0021.
- 18 Mar 2018Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 ratReference: Edwards AB, Cross JL, Anderton RS, Knuckey NW, Meloni BP. (2018). Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improve behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat. Molecular Brain, 11:1-12. DOI: 10.1186/s13041-018-0352-0
- 07 Mar 2018Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studiesReference: Milani D, Bakeberg MC, Cross JL, Clark VW, Anderton, RS, Blacker DJ, Knuckey NW, Meloni BP (2018). Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies. PloS One, 13:e0193884. DOI: 10.1371/journal.pone.0193884.
- 26 Aug 2018Assessment of therapeutic window for poly-arginine-18D (R18D) in a P7 rat model of perinatal hypoxic-ischaemic encephalopathyReference: Edwards AB, Anderton RS, Knuckey NW, Meloni BP. (2018). Assessment of therapeutic window for poly-arginine-18D (R18D) in a P7 rat model of perinatal hypoxic-ischaemic encephalopathy. Journal of Neuroscience Research, 96:1816-1826. DOI: 10.1002/jnr.24315.
- 02 Jan 2019Poly-arginine Peptide R18D Reduces Neuroinflammation and Functional Deficits Following Traumatic Brain Injury in the Long-Evans RatReference: Chiu LS, Anderton RS, Cross, JL, Clark VW, Knuckey NW, Meloni BP (2019). Poly-arginine peptide R18D reduces neuroinflammation and functional deficits following traumatic brain injury in the Long Evans Rat. International Journal of Peptide Research and Therapeutics, 16:1-8. DOI: org/10.1007/s10989-018-09799-8.
- 17 Jul 2019Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicityReference: MacDougall G, Anderton RS, Mastaglia FL, Knuckey NW, Meloni BP (2019). Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity. Molecular Brain, 12:66. DOI: 10.1186/s13041-019-0486-8.
- 07 Nov 2019Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the ratReference: Liddle L, Reinders R, South SM, David Blacker DJ, Knuckey NW, Colbourne F, Melon BP (2019). Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat. PloS One, 4:e0224870. DOI: org/10.1371/journal.pone.0224870.
- 07 Nov 2019Poly-arginine peptides R18 and R18D improve functional outcomes after endothelin-1-induced stroke in the Sprague Dawley ratReference: Meloni BP, South SM., Gill, DA, Marriott AL, Déziel RA, Jacques A, Blacker DJ, Knuckey NW (2019). Poly-arginine peptides R18 and R18D improve functional outcomes after endothelin-1-induced stroke in the Sprague Dawley rat. Journal of Neuropathology and Experimental Neurology, 78:426-435. DOI: 10.1093/jnen/nlz014.
- 04 Jan 2020In vitro cellular uptake and neuroprotective efficacy of poly-arginine-18 (R18) and poly-ornithine-18 (O18) peptides: critical role of arginine guanidinium head groups for neuroprotectionReference: MacDougall G, Anderton RS, Ouliel E, Junjie Gao J, Redmond SL, Knuckey NW, Meloni BP (2020). In vitro cellular uptake and neuroprotective efficacy of poly-arginine-18 (R18) and poly-ornithine-18 (O18) peptides: critical role of arginine guanidinium head groups for neuroprotection. Molecular and Cellular Biochemistry, 464:27-38. DOI: 10.1007/s11010-019-03646-0
- 25 Feb 2020Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of ActionReference: Meloni BP, Mastaglia FL, Knuckey NW (2020). Cationic arginine-rich peptides (CARPs): A novel class of neuroprotective agents with a multimodal mechanism of action. Frontiers in Neurology, 11:108. DOI: 10.3389/fneur.2020.00108.
- 30 Mar 2020Tissue distribution of intravenously administrated poly-arginine peptide R18D in healthy male Sprague–Dawley ratsReference: Chiu LS, Anderton RS, Clark VW, Knuckey NW, Mardon K, Rajiv Bhalla R, Meloni BP (2020). Tissue distribution of intravenously administrated poly-arginine peptide R18D in healthy male Sprague-Dawley rats. Future Drug Discovery, 2:2. DOI: org/10.4155/fdd-2019-0039.
- 17 Apr 2020Poly-arginine peptide-18 (R18) reduces brain injury and improves functional outcomes in a non-human primate stroke modelReference: Meloni BP, Chen, Y, Harrison KA, Nashed JY, Blacker DJ, South SM, Anderton RS, Mastaglia FL, Winterborn A, Knuckey NW, Cook DJ (2020). Poly-arginine peptide-18 (R18) reduces brain injury and improves functional outcomes in a non-human primate stroke model. Neurotherapeutics, 17:627-634. DOI: 10.1007/s13311-019-00809-1.
- 01 May 2020Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18DReference: Kenna JE, Anderton RS, Knuckey NW, Meloni BP (2020). Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D. Neurochemical Research, 45:1215-1229. DOI: org/10.1007/s11064-020-03004-3.
- 21 Jun 2020Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley RatsReference: Chiu LS, Anderton RS, Clark VW, Cross, JL, Knuckey NW, Meloni BP (2020). Effect of poly-arginine peptide R18D following a traumatic brain injury in Sprague-Dawley rats. Current Therapeutic Research, 2020, 92:100584.
- 25 Jul 2020Poly-arginine-18 (R18) Confers Neuroprotection through Glutamate Receptor Modulation, Intracellular Calcium Reduction, and Preservation of Mitochondrial FunctionReference: MacDougall G, Anderton RS, Trimble A, Mastaglia FL, Knuckey NW, Meloni BP (2020). Polyarginine-18 (R18) confers neuroprotection against excitotoxicity through glutamate receptor modulation, intracellular calcium reduction, and preservation of mitochondrial function. Molecules.
- 25 May 2021Comparative Assessment of the Proteolytic Stability and Impact of Poly-Arginine Peptides R18 and R18D on Infarct Growth and Penumbral Tissue Preservation Following Middle Cerebral Artery Occlusion in the Sprague Dawley Rat.Reference: Milani D, Clark VW, Feindel KW, Blacker DJ, Bynevelt M, Edwards AB, Anderton RS, Knuckey NW, Meloni BP. Neurochem Res. 2021 May;46(5):1166-1176. doi: 10.1007/s11064-021-03251-y. Epub 2021 Feb 1. PMID: 33523394
- 28 Oct 2021Arginine and Arginine-Rich Peptides as Modulators of Protein Aggregation and Cytotoxicity Associated With Alzheimer’s Disease.Reference: Mamsa SSA, Meloni BP. Front Mol Neurosci. 2021 Oct 28;14:759729. doi: 10.3389/fnmol.2021.759729. eCollection 2021. PMID: 34776866 Free PMC article. Review.
- 01 Jul 2022Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysisReference: Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis. Meloni BP, Blacker DJ, Edwards AB, Knuckey NW.J Thromb Thrombolysis. 2022 Jul;54(1):172-182. doi: 10.1007/s11239-022-02642-4. Epub 2022 Mar 19.PMID: 35305237 Free PMC article.
- 01 Jul 2022Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysisReference: Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis. Edwards AB, Mastaglia FL, Knuckey NW, Yip KH, Meloni B.Biochem Biophys Rep. 2022 Jul 1;31:101305. doi: 10.1016/j.bbrep.2022.101305. eCollection 2022 Sep.PMID: 35812346
